One embodiment includes an adaptive sample quantization system. The adaptive sample quantization system includes an antenna to receive a radio frequency (RF) signal having data encoded therein, and analog antenna electronics configured to convert the RF signal to an analog electrical signal. The system also includes an analog-to-digital converter (ADC) directly coupled to the antenna and configured to generate a plurality of consecutive digital samples of the RF signal. The system further includes a quantizer to determine a mode based on the plurality of consecutive digital samples and to select at least one threshold based on the determined mode. The quantizer can further compare each digital sample with the at least one threshold to generate a corresponding one of a plurality of output samples having a reduced number of bits relative to the respective digital sample to substantially mitigate potential interference and facilitate extraction of the data.