A spray shield for the pipe connection flange of pipes carrying hazardous fluids. A band composed of metal or other suitable material encompasses a pipe flange and supports a spray diffusion mesh or device so that any spray of pressurized leaked fluid is coalesced to drops or streams of leaked fluid which descend by gravity for collection rather than being sprayed into the environment in the vicinity of the leaking flange joint. The spray shield band is secured about the flange by an over-center latch mechanism that tightens the band and spray diffusion mesh around the flange connection. A locking pin or lockout device is inserted through aligned holes of the latch mechanism when closed and functions to secure the latch against release and movement from its latched position.