Invention Grant
US08926992B2 Mucosal vaccines with chitosan adjuvant and meningococcal antigens
有权
粘膜疫苗与壳聚糖佐剂和脑膜炎球菌抗原
- Patent Title: Mucosal vaccines with chitosan adjuvant and meningococcal antigens
- Patent Title (中): 粘膜疫苗与壳聚糖佐剂和脑膜炎球菌抗原
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Application No.: US10514207Application Date: 2003-05-14
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Publication No.: US08926992B2Publication Date: 2015-01-06
- Inventor: Giuseppe Del Guidice , Barbara Baudner
- Applicant: Giuseppe Del Guidice , Barbara Baudner
- Applicant Address: CH Basel NL Leiden
- Assignee: Novartis AG,Universiteit Leiden
- Current Assignee: Novartis AG,Universiteit Leiden
- Current Assignee Address: CH Basel NL Leiden
- Agency: Morrison & Foerster LLP
- Priority: GB0302218.3 20030130
- International Application: PCT/IB03/02382 WO 20030514
- International Announcement: WO03/094834 WO 20031120
- Main IPC: A61K39/095
- IPC: A61K39/095 ; A61K39/108

Abstract:
The invention provides immunogenic compositions comprising (a) a capsular saccharide antigen from serogroup C of N. meningitidis, and (b) a chitosan adjuvant. The composition preferably comprises (c) one or more further antigens and/or (d) one or more further adjuvants. The compositions are particularly suitable for mucosal delivery, including intranasal delivery. The invention also provides immunogenic compositions for mucosal delivery comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of N. meningitidis. It is preferred that the capsular saccharides in the compositions of the invention are conjugated to carrier protein(s) and/or are oligosaccharides. Conjugated oligosaccharide antigens are particularly preferred.
Public/Granted literature
- US20060051378A1 Mucosal vaccines with chitosan adjuvant and meningococcal antigens Public/Granted day:2006-03-09
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