Invention Grant
- Patent Title: Misuse preventative, controlled release formulation
- Patent Title (中): 滥用预防性,控释制剂
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Application No.: US14305935Application Date: 2014-06-16
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Publication No.: US08927014B2Publication Date: 2015-01-06
- Inventor: Miloud Rahmouni , Sonia Gervais , Vinayak Sant , Damon Smith , Frederic Duffayet , Shams Rustom , Ali El-Jammal , Jean-Michel Ndong , Ali Bichara
- Applicant: Paladin Labs Inc. , Paladin Labs (Barbados) Inc. , Paladin Labs Europe Limited
- Applicant Address: CA Montreal BB Hastings IE Dublin
- Assignee: Paladin Labs Inc.,Paladin Labs (Barbados) Inc.,Paladin Labs Europe Limited
- Current Assignee: Paladin Labs Inc.,Paladin Labs (Barbados) Inc.,Paladin Labs Europe Limited
- Current Assignee Address: CA Montreal BB Hastings IE Dublin
- Agency: Goodwin Procter LLP
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K9/28

Abstract:
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. A second layer comprises a superabsorbent material. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material creates a hard gel that traps the microparticles. The hard gel and microparticles provide controlled release of the pharmaceutically active agent.
Public/Granted literature
- US20140294955A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION Public/Granted day:2014-10-02
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