Invention Grant
- Patent Title: Granulating process and thus prepared granulate
- Patent Title (中): 造粒过程，从而制备颗粒
-
Application No.: US13387239Application Date: 2010-02-24
-
Publication No.: US08927021B2Publication Date: 2015-01-06
- Inventor: Zoltan Toelgyesi , Zsolt Zsigmond , Gyoergy Ujfalussy , Magdolna Leventiszne Huszar , Peter Tonka-Nagy , Monika Agyagos
- Applicant: Zoltan Toelgyesi , Zsolt Zsigmond , Gyoergy Ujfalussy , Magdolna Leventiszne Huszar , Peter Tonka-Nagy , Monika Agyagos
- Applicant Address: HU Budapest
- Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszventarsasag
- Current Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszventarsasag
- Current Assignee Address: HU Budapest
- Agency: Lucas & Mercanti, LLP
- Agent Jonathan Myers
- Priority: HUP0900468 20090728; HUP1000044 20100125
- International Application: PCT/HU2010/000022 WO 20100224
- International Announcement: WO2011/012912 WO 20110203
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61P3/06 ; B05D1/02 ; A61K31/397 ; A61K9/20 ; A61K9/50 ; A61K31/366 ; A61K31/40 ; A61K31/505 ; A61K45/06
Abstract:
The present invention relates to a process for manufacturing microcrystalline ezetimibe containing granulate, wherein a) ezetimibe is dissolved; b) the dissolved ezetimibe is precipitated with water, which if necessary contains pharmaceutical excipients, preferably lauryl-sulfate derivatives, and c) granulates are formed from the obtained suspension by spraying the suspension onto pharmaceutical excipients. A further aspect of the present invention is the granulate obtained by the present process and the pharmaceutical composition containing such granulate.
Public/Granted literature
- US20120164227A1 NEW GRANULATING PROCESS AND THUS PREPARED GRANULATE Public/Granted day:2012-06-28
Information query
