Invention Grant
US08927023B2 Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions
有权
用于纳米颗粒药物组合物的生物相容性，非生物降解性，无毒性聚合物
- Patent Title: Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions
- Patent Title (中): 用于纳米颗粒药物组合物的生物相容性，非生物降解性，无毒性聚合物
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Application No.: US13633638Application Date: 2012-10-02
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Publication No.: US08927023B2Publication Date: 2015-01-06
- Inventor: Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
- Applicant: Fresenius Kabi Oncology Limited
- Applicant Address: IN
- Assignee: Fresenius Kabi Oncology Limited
- Current Assignee: Fresenius Kabi Oncology Limited
- Current Assignee Address: IN
- Agency: Schwegman Lundberg & Woessner, P.A.
- Priority: IN1190/KOL/2005 20051228
- Main IPC: A61K47/30
- IPC: A61K47/30 ; A61K47/32 ; C08F220/56 ; C08F222/12 ; C08F226/10 ; C08F222/38
Abstract:
The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.
Public/Granted literature
- US20130274211A1 BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS Public/Granted day:2013-10-17
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