Invention Grant
- Patent Title: Methods for detecting dithio-containing proteins using quenched fluorophores conjugated to peptides via linkers containing dithio groups
- Patent Title (中): 使用含有二硫基基团的接头与肽偶联的淬灭荧光团检测含二硫蛋白的方法
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Application No.: US13665478Application Date: 2012-10-31
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Publication No.: US08927291B2Publication Date: 2015-01-06
- Inventor: Daniel S. Sem
- Applicant: Marquette University
- Applicant Address: US WI Milwaukee
- Assignee: Marquette University
- Current Assignee: Marquette University
- Current Assignee Address: US WI Milwaukee
- Agency: Andrus Intellectual Property Law, LLP
- Main IPC: G01N21/64
- IPC: G01N21/64 ; C07C323/35 ; C07C323/52 ; C07K5/02 ; G01N33/58 ; G01N33/68
Abstract:
Disclosed are dithio compounds that include a quenched fluorophore and a non-fluorophore peptide linked via a dithio bond to the fluorophore. The dithio compounds may be used in methods for detecting thiol-containing compounds or dithio-containing compounds. The dithio compounds also may be used as cellular probes where the peptide portion of the compounds targets the compounds to a specific cellular location.
Public/Granted literature
- US20130122600A1 Quenched Fluorophores Conjugated to Peptides Via Linkers Containing Dithio Groups Public/Granted day:2013-05-16
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