Invention Grant
- Patent Title: 5′ phosphate mimics
- Patent Title (中): 5'磷酸酯类似物
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Application No.: US13382346Application Date: 2010-07-07
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Publication No.: US08927513B2Publication Date: 2015-01-06
- Inventor: Muthiah Manoharan , Kallanthottathil G. Rajeev , Marija Prhavc , Ivan Zlatev
- Applicant: Muthiah Manoharan , Kallanthottathil G. Rajeev , Marija Prhavc , Ivan Zlatev
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: LeClairRyan
- Agent Jeffrey N. Townes
- International Application: PCT/US2010/041209 WO 20100707
- International Announcement: WO2011/005860 WO 20110113
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C07H19/11 ; C07H19/213
Abstract:
The present invention provides nucleosides and oligonucleotides comprising a 5′ phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
Public/Granted literature
- US20120157511A1 5' PHOSPHATE MIMICS Public/Granted day:2012-06-21
Information query
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