Provided herein are methods of reducing adhesion formation in a subject, for example, post-surgical abdominal and pelvic adhesions. The methods include the step of administering to the subject in need thereof a compound chosen from 2′,3′-cyclic adenosine monophosphate, analogs thereof, and pharmaceutically acceptable salts thereof, able to reduce the formation of adhesions in a subject as compared to adenosine monophosphate, in an amount effective to reduce adhesions.