Invention Grant
- Patent Title: Macrocyclic compounds as antiviral agents
- Patent Title (中): 大环化合物作为抗病毒剂
-
Application No.: US12668987Application Date: 2008-07-17
-
Publication No.: US08927569B2Publication Date: 2015-01-06
- Inventor: Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
- Applicant: Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Julie M. Lake; Laura M. Ginkel
- International Application: PCT/GB2008/050585 WO 20080717
- International Announcement: WO2009/010804 WO 20090122
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/33 ; C07D245/00 ; C07D225/04 ; C07D295/00 ; C07K5/087 ; C07K5/083
Abstract:
A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
Public/Granted literature
- US20100183551A1 Macrocyclic Compounds As Antiviral Agents Public/Granted day:2010-07-22
Information query
