Invention Grant
US08927692B2 Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same
有权
共识的前列腺抗原，编码相同的核酸分子和疫苗以及包含它们的用途
- Patent Title: Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same
- Patent Title (中): 共识的前列腺抗原，编码相同的核酸分子和疫苗以及包含它们的用途
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Application No.: US13883978Application Date: 2011-11-14
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Publication No.: US08927692B2Publication Date: 2015-01-06
- Inventor: David B Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y Sardesai , Mathura P Ramanathan
- Applicant: David B Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y Sardesai , Mathura P Ramanathan
- Applicant Address: US PA Philadelphia US PA Plymouth Meeting
- Assignee: The Trustees of the University of Pennsylvania,Inovio Pharmaceuticals, Inc.
- Current Assignee: The Trustees of the University of Pennsylvania,Inovio Pharmaceuticals, Inc.
- Current Assignee Address: US PA Philadelphia US PA Plymouth Meeting
- Agency: Riverside Law LLP
- International Application: PCT/US2011/060592 WO 20111114
- International Announcement: WO2012/065164 WO 20120518
- Main IPC: C07K7/00
- IPC: C07K7/00 ; A61K39/00
Abstract:
Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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