Invention Grant
US08927704B2 Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same
有权
能够控制iNOS表达的感知寡核苷酸和包含其的组合物
- Patent Title: Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same
- Patent Title (中): 能够控制iNOS表达的感知寡核苷酸和包含其的组合物
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Application No.: US12303914Application Date: 2007-06-07
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Publication No.: US08927704B2Publication Date: 2015-01-06
- Inventor: Tadayoshi Okumura , Mikio Nishizawa , Yasuo Kamiyama , Koji Wakame , Takehito Miura
- Applicant: Tadayoshi Okumura , Mikio Nishizawa , Yasuo Kamiyama , Koji Wakame , Takehito Miura
- Applicant Address: JP Hokkaido JP Osaka
- Assignee: Amino Up Chemical Co., Ltd,Kansai Medical University
- Current Assignee: Amino Up Chemical Co., Ltd,Kansai Medical University
- Current Assignee Address: JP Hokkaido JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JP2006-159730 20060608
- International Application: PCT/JP2007/061565 WO 20070607
- International Announcement: WO2007/142304 WO 20071213
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113

Abstract:
The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
Public/Granted literature
- US20100248364A1 SENSE OLOGONUCLEOTIDE CAPABLE OF CONTROLLING THE EXPRESSION OF iNOS AND COMPOSITION COMPRISING THE SAME Public/Granted day:2010-09-30
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