Invention Grant
US08927704B2 Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same 有权
能够控制iNOS表达的感知寡核苷酸和包含其的组合物

Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same
Abstract:
The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
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