Invention Grant
US08927708B2 Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine
有权
合成7,8-二甲氧基-1,3-二氢-2H-3-苯并吖庚因-2-酮化合物的方法及应用于伊伐布雷定
- Patent Title: Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine
- Patent Title (中): 合成7,8-二甲氧基-1,3-二氢-2H-3-苯并吖庚因-2-酮化合物的方法及应用于伊伐布雷定
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Application No.: US14223143Application Date: 2014-03-24
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Publication No.: US08927708B2Publication Date: 2015-01-06
- Inventor: Alexandre Le Flohic
- Applicant: Les Laboratoires Servier
- Applicant Address: FR Suresnes Cedex
- Assignee: Les Laboratoires Servier
- Current Assignee: Les Laboratoires Servier
- Current Assignee Address: FR Suresnes Cedex
- Agency: Hueschen and Sage
- Priority: FR1352741 20130326
- Main IPC: C07D223/16
- IPC: C07D223/16 ; C07C235/34
Abstract:
Process for the synthesis of the compound of formula (I): wherein R represents a para-methoxybenzyl (PMB) group or the following group: Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
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