Invention Grant
- Patent Title: Asymmetric reduction process
- Patent Title (中): 不对称还原过程
-
Application No.: US14003385Application Date: 2012-03-08
-
Publication No.: US08927740B2Publication Date: 2015-01-06
- Inventor: Raffaella Volpicelli , Mauro Andretto , Livius Cotarca , Antonio Nardi , Massimo Verzini
- Applicant: Raffaella Volpicelli , Mauro Andretto , Livius Cotarca , Antonio Nardi , Massimo Verzini
- Applicant Address: IT Bresso (Milan)
- Assignee: Zach System S.P.A.
- Current Assignee: Zach System S.P.A.
- Current Assignee Address: IT Bresso (Milan)
- Agency: Silvia Salvadori, P.C.
- Priority: ITMI2011A0365 20110310; ITMI2011A1028 20110608
- International Application: PCT/EP2012/054023 WO 20120308
- International Announcement: WO2012/120086 WO 20120913
- Main IPC: C07D495/04
- IPC: C07D495/04
Abstract:
The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.
Public/Granted literature
- US20130338377A1 ASYMMETRIC REDUCTION PROCESS Public/Granted day:2013-12-19
Information query
