A smart interlock system and a working method thereof. The smart interlock system includes a lock (1), an unlocking device (2) and a logic generator (3). The logic generator (3) comprises a logic generation module and a logic communication module. The logic generation module generates identity identification logic and state identification logic of the lock, and the two kinds of logic are sent to the unlocking device (2) through the logic communication module. The lock (1) comprises a lock tongue (102), a lock head (106) and an identity and state converting module (104). The unlocking device (2) comprises an unlocking module for starting the lock head to move, an identity identifying module (201) and a communication module. The identity identifying module (201) of the unlocking device identifies the identity of the lock, receives an identity label information which is transferred from the identity and state converting module (104) of the lock, recognizes the state of the lock tongue (102), and judges whether to unlock the lock or not according to the identity identification logic and state identification logic of the lock which are received from the logic generator (3). The smart interlock system works flexibly and enables electric anti-misoperation to be reliable and intelligent.