One embodiment is directed to a distributed antenna system (DAS) including a host unit and a plurality of remote units. The host unit includes a plurality of base transceiver stations and a switch. Each of the base transceiver stations is configured to provide a downstream baseband digital signal to the switch and to receive an upstream baseband digital signal from the switch, wherein each downstream baseband digital signal and upstream baseband digital signal is a digital representation of the RF channel at baseband of the respective base transceiver station. The switch is configured to route each of the downstream baseband digital signals to a respective subset of the remote units as one or more downstream serial data streams and to route each of the upstream baseband digital signals from one or more upstream serial data streams to a respective subset of the base transceiver stations.