A system and method for ulcer detection which may generate a vector of grades including grades indicative of a probability that the image includes an ulcer, for example an ulcer of specific type. For each grade, generating may include finding ulcer candidates within the image, and for each ulcer candidate, building a property vector describing properties of the ulcer candidate and employing a trained classifier to generate the grade from the property vector. The grades may be combined to obtain an indication or score of the probability that the image includes an ulcer.