A sensor module for detecting and/or measuring physiological information from a subject includes a housing with at least one optical emitter and at least one optical detector supported by the housing. A first light guide is in optical communication with the at least one optical emitter and is configured to deliver light from the at least one optical emitter into a body of a subject. A second light guide is in optical communication with the at least one optical detector and is configured to collect light from the body of the subject. The sensor module includes a motion sensor and a processor. The motion sensor is configured to sense motion information from the subject and the processor is configured to remove motion artifacts from signals produced by the at least one optical detector in response to signals produced by the motion sensor.