A method and a system for timing analysis of a VLSI circuit or chip design considering manufacturing and environmental variations, where the design includes multiple instances of a gate or macro instantiated at more than one voltage domain by sharing and re-using abstracts. The timing analysis of the chip includes a macro abstract instantiated in a voltage domain different from the domain during abstract generation. Timing models are re-used across chip voltage domains or across chip designs. Moreover, a statistical timing analysis of a chip design takes into consideration the voltage domains wherein at least one timing abstract model generation time voltage domain condition differs from the macro instantiation domain in the chip. The invention further provides sharing and re-using the statistical timing models or abstracts.