A fitting assembly is provided having a nut and a self-releasing ferrule, which in certain embodiments may be assembled by an operator. The fitting assembly includes a nut with a first end, and a second end that defines a slot, and a ferrule with a first end that defines one or more slots, and a second end, with the second end of the nut adapted to receive the first end of the ferrule, the second end of the ferrule adapted to be received in a component or fitting of a liquid chromatography system. The nut and ferrule of the fitting assembly have passageways therethrough for receiving and removably holding tubing.