Invention Grant
US08932818B2 Screening assays for compounds that modulate programmed ribosomal frameshifting
有权
调节程序性核糖体移码的化合物的筛选测定
- Patent Title: Screening assays for compounds that modulate programmed ribosomal frameshifting
- Patent Title (中): 调节程序性核糖体移码的化合物的筛选测定
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Application No.: US13058613Application Date: 2009-08-13
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Publication No.: US08932818B2Publication Date: 2015-01-13
- Inventor: Sergey V. Paushkin , Nikolai A. Naryshkin , Ellen Welch
- Applicant: Sergey V. Paushkin , Nikolai A. Naryshkin , Ellen Welch
- Applicant Address: US NJ South Plainfield
- Assignee: PTC Therapeutics, Inc.
- Current Assignee: PTC Therapeutics, Inc.
- Current Assignee Address: US NJ South Plainfield
- Agency: Jones Day
- International Application: PCT/US2009/004636 WO 20090813
- International Announcement: WO2010/019243 WO 20100218
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/66 ; C12Q1/48 ; C12Q1/34 ; C12Q1/02
Abstract:
The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation of compounds that modulate ribosomal frameshifting. In particular, the present invention relates to the use of nucleic acid constructs to identify or validate compounds capable of modulating the efficiency of programmed ribosomal frameshifting and the use of compounds that modulate the efficiency of programmed ribosomal frameshifting to inhibit the replication or infectivity of viruses that employ programmed ribosomal frameshifting.
Public/Granted literature
- US20110213005A1 METHODS FOR TREATING VIRAL INFECTIONS Public/Granted day:2011-09-01
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