Invention Grant
- Patent Title: Method for selecting reduced differentiation resistance human induced pluripotent stem cells
- Patent Title (中): 选择降低分化能力的人诱导多能干细胞的方法
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Application No.: US13704584Application Date: 2011-06-15
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Publication No.: US08932857B2Publication Date: 2015-01-13
- Inventor: Shinya Yamanaka , Kazutoshi Takahashi , Mari Ohnuki
- Applicant: Shinya Yamanaka , Kazutoshi Takahashi , Mari Ohnuki
- Applicant Address: JP Kyoto
- Assignee: Kyoto University
- Current Assignee: Kyoto University
- Current Assignee Address: JP Kyoto
- Agency: Knobbe, Martens, Olson & Bear, LLP
- International Application: PCT/JP2011/064195 WO 20110615
- International Announcement: WO2011/158960 WO 20111222
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/074
Abstract:
The present invention provides a method for selecting human induced pluripotent stem (iPS) cells which can be safely used for transplantation. That is, the present invention provides a method for selecting human iPS cells having reduced differentiation resistance, comprising the steps of: (1) inducing differentiation of human iPS cells; (2) detecting remaining undifferentiated cells after the step (1); and (3) selecting human iPS cells whose rate of remaining undifferentiated cells detected in step (2) is equivalent to or not more than that of control cells.
Public/Granted literature
- US20130089870A1 METHOD FOR SELECTING HUMAN INDUCED PLURIPOTENT STEM CELLS Public/Granted day:2013-04-11
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