Invention Grant
- Patent Title: Treatment of B-cell lymphoma with microRNA
- Patent Title (中): 用microRNA处理B细胞淋巴瘤
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Application No.: US13876725Application Date: 2011-09-29
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Publication No.: US08933051B2Publication Date: 2015-01-13
- Inventor: Vanessa Craig , Anne Mueller
- Applicant: Vanessa Craig , Anne Mueller
- Applicant Address: CH Zurich
- Assignee: University of Zurich
- Current Assignee: University of Zurich
- Current Assignee Address: CH Zurich
- Agency: Nutter McClennen & Fish LLP
- Agent Konstantin Linnik; Isaac A. Hubner
- Priority: EP10182950 20100930
- International Application: PCT/EP2011/066980 WO 20110929
- International Announcement: WO2012/041959 WO 20120405
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL.
Public/Granted literature
- US20130195858A1 TREATMENT OF B-CELL LYMPHOMA WITH MICRORNA Public/Granted day:2013-08-01
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