Invention Grant
US08933053B2 Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer
有权
用于治疗癌症的5-氟-2'-脱氧尿苷的氨基磷酸衍生物
- Patent Title: Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer
- Patent Title (中): 用于治疗癌症的5-氟-2'-脱氧尿苷的氨基磷酸衍生物
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Application No.: US14000682Application Date: 2012-02-29
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Publication No.: US08933053B2Publication Date: 2015-01-13
- Inventor: Christopher McGuigan , Jan Balzarini , Magdalena Slusarczyk , Blanka Gonczy , Paola Murziani
- Applicant: Christopher McGuigan , Jan Balzarini , Magdalena Slusarczyk , Blanka Gonczy , Paola Murziani
- Applicant Address: GB Camberley
- Assignee: NuCana BioMed Limited
- Current Assignee: NuCana BioMed Limited
- Current Assignee Address: GB Camberley
- Agency: Fish & Richardson P.C.
- Priority: GB1103582.1 20110301; GB1105660.3 20110401
- International Application: PCT/GB2012/050457 WO 20120229
- International Announcement: WO2012/117246 WO 20120907
- Main IPC: A61K31/7072
- IPC: A61K31/7072 ; A61K45/06 ; C07H19/10 ; C07F9/6584 ; C07F9/655 ; C07F9/6558
Abstract:
Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.
Public/Granted literature
- US20140057866A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER Public/Granted day:2014-02-27
Information query
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