Invention Grant
US08933070B2 Methods of targeting PTEN mutant diseases and compositions therefor
有权
靶向PTEN突变体疾病及其组合物的方法
- Patent Title: Methods of targeting PTEN mutant diseases and compositions therefor
- Patent Title (中): 靶向PTEN突变体疾病及其组合物的方法
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Application No.: US13807816Application Date: 2011-07-04
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Publication No.: US08933070B2Publication Date: 2015-01-13
- Inventor: Guohua Pan , Jacqueline M. Mason , Xin Wei , Miklos Feher
- Applicant: Guohua Pan , Jacqueline M. Mason , Xin Wei , Miklos Feher
- Applicant Address: CA Toronto
- Assignee: University Health Network
- Current Assignee: University Health Network
- Current Assignee Address: CA Toronto
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- International Application: PCT/CA2011/000776 WO 20110704
- International Announcement: WO2012/000103 WO 20120105
- Main IPC: A61K31/553
- IPC: A61K31/553 ; A61K31/00 ; A61K31/535 ; C07D273/00 ; C07D211/00 ; A61K31/495 ; A61K31/416 ; A61K31/4439 ; A61K31/497
Abstract:
Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation. In particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.
Public/Granted literature
- US20130123273A1 METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR Public/Granted day:2013-05-16
Information query
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