Invention Grant
US08933085B2 Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
有权
环丁基取代吡咯并吡啶和吡咯并嘧啶衍生物作为JAK抑制剂
- Patent Title: Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
- Patent Title (中): 环丁基取代吡咯并吡啶和吡咯并嘧啶衍生物作为JAK抑制剂
-
Application No.: US13300094Application Date: 2011-11-18
-
Publication No.: US08933085B2Publication Date: 2015-01-13
- Inventor: James D. Rodgers , Stacey Shepard , Wenyu Zhu , Lixin Shao , Joseph Glenn
- Applicant: James D. Rodgers , Stacey Shepard , Wenyu Zhu , Lixin Shao , Joseph Glenn
- Applicant Address: US DE Wilmington
- Assignee: Incyte Corporation
- Current Assignee: Incyte Corporation
- Current Assignee Address: US DE Wilmington
- Agency: Fish & Richardson P.C.
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D471/04 ; A61K31/519 ; A61K31/437 ; A61P35/00 ; A61P29/00 ; A61P37/06 ; A61P17/06 ; A61P17/08 ; A61P19/08 ; A61P19/10
Abstract:
The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I: wherein X, Y, Z, L, A, R5, n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
Public/Granted literature
- US20120149681A1 CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS Public/Granted day:2012-06-14
Information query
