Invention Grant
US08933111B2 Crystalline form of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester
有权
（2S，4R）-5-联苯-4-基-2-羟甲基-2-甲基-4 - [（1H- [1,2,3]三唑-4-羰基） - 氨基] - 戊酸的结晶形式 5-甲基-2-氧代 - [1,3]二氧杂环戊烯-4-基甲酯
![Crystalline form of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester](/docs/US/2015-01-13/US08933111B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline form of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester
- Patent Title (中): （2S，4R）-5-联苯-4-基-2-羟甲基-2-甲基-4 - [（1H- [1,2,3]三唑-4-羰基） - 氨基] - 戊酸的结晶形式 5-甲基-2-氧代 - [1,3]二氧杂环戊烯-4-基甲酯
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Application No.: US13767285Application Date: 2013-02-14
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Publication No.: US08933111B2Publication Date: 2015-01-13
- Inventor: Miroslav Rapta
- Applicant: Miroslav Rapta
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A01N43/64
- IPC: A01N43/64 ; A61K31/41 ; A01N43/54 ; A61K31/505 ; A01N43/56 ; A61K31/415 ; A61K39/00 ; A61K39/38 ; A61K31/4192 ; C07D405/12 ; A61K45/06
![Crystalline form of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester](/abs-image/US/2015/01/13/US08933111B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides a crystalline form of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester or its tautomer. This invention also provides pharmaceutical compositions comprising the crystalline compound, processes and intermediates for preparing the crystalline compound, and methods of using the crystalline compound to treat diseases.
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