Invention Grant
- Patent Title: Process for preparing Bosentan monohydrate and it's intermediates
- Patent Title (中): 制备波生坦一水合物及其中间体的方法
-
Application No.: US13824620Application Date: 2011-09-22
-
Publication No.: US08933226B2Publication Date: 2015-01-13
- Inventor: Livius Cotarca , Massimo Verzini , Elisa Melotto , Ivan Michieletto , Alfonso Melloni , Paolo Maragni , Raffaella Volpicelli , Mauro Andretto , Corrado Colli
- Applicant: Livius Cotarca , Massimo Verzini , Elisa Melotto , Ivan Michieletto , Alfonso Melloni , Paolo Maragni , Raffaella Volpicelli , Mauro Andretto , Corrado Colli
- Applicant Address: IT Bresso (Milano)
- Assignee: Zach Systems S.p.A.
- Current Assignee: Zach Systems S.p.A.
- Current Assignee Address: IT Bresso (Milano)
- Agent Silvia Salvadori, P.C.
- Priority: EP10185950 20101001
- International Application: PCT/EP2011/066531 WO 20110922
- International Announcement: WO2012/041764 WO 20120405
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D239/69 ; C07C31/20
Abstract:
The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
Public/Granted literature
- US20130253195A1 PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATED Public/Granted day:2013-09-26
Information query
