Invention Grant
US08933248B2 3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
有权
3-取代-3-羟基羟吲哚衍生物及其制备方法
- Patent Title: 3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
- Patent Title (中): 3-取代-3-羟基羟吲哚衍生物及其制备方法
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Application No.: US13921957Application Date: 2013-06-19
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Publication No.: US08933248B2Publication Date: 2015-01-13
- Inventor: Mandapati Mohan Rao , Parvathaneni Sai Prathima
- Applicant: Council of Scientific & Industrial Research
- Applicant Address: IN New Delhi
- Assignee: Council of Scientific & Industrial Research
- Current Assignee: Council of Scientific & Industrial Research
- Current Assignee Address: IN New Delhi
- Agent Maschoff Brennan
- Priority: IN1914/DEL/2012 20120621; IN1914/DEL/2012 20130402
- Main IPC: C07D209/38
- IPC: C07D209/38
Abstract:
The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II).
Public/Granted literature
- US20130345438A1 3-SUBSTITUTED-3-HYDROXY OXINDOLE DERIVATIVES AND PROCESS FOR PREPARATION THEREOF Public/Granted day:2013-12-26
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