Invention Grant
- Patent Title: Rosuvastatin calcium intermediate and method for preparing the same
- Patent Title (中): 罗苏伐他汀钙中间体及其制备方法
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Application No.: US13587913Application Date: 2012-08-16
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Publication No.: US08933269B2Publication Date: 2015-01-13
- Inventor: Wenqing Lin , Hongjie Zheng , Xiaobo Liu
- Applicant: Wenqing Lin , Hongjie Zheng , Xiaobo Liu
- Applicant Address: CN Chongqing
- Assignee: Porton Fine Chemicals Ltd.
- Current Assignee: Porton Fine Chemicals Ltd.
- Current Assignee Address: CN Chongqing
- Agency: Matthias Scholl P.C.
- Agent Matthias Scholl
- Priority: CN201010162885 20100405; CN201010179187 20100521
- Main IPC: C07C59/00
- IPC: C07C59/00 ; C07F9/535 ; C07C69/732 ; C07C29/36 ; C07C67/22 ; C07C67/29 ; C07C67/31 ; C07C67/313 ; C07C69/734 ; C07C69/78

Abstract:
A method for preparing a rosuvastatin calcium intermediate, including a) contacting a halogenated ethene with magnesium metal to obtain a halogenated ethene Grignard reagent, and carrying out a Grignard reaction between the halogenated ethene Grignard reagent and R-epichlorohydrin; b) adding sodium cyanide for carrying out a nucleophilic substitution reaction; c) adding alcohol for carrying out an alcoholysis reaction; d) adding a basic solvent for carrying out protection of a first hydroxyl group; e) selectively oxidizing a second hydroxyl group; and f) adding triphenylphosphine in alkaline condition for carrying out a Wittig reaction.
Public/Granted literature
- US20120310000A1 ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME Public/Granted day:2012-12-06
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