Methods and apparatus are provided for transmitting and receiving reference signals through distributed antennas deployed within a service area of a base station in a mobile communication system. First control information, including at least two scrambling factor combinations, is received at a terminal from the base station. Second control information, indicating one of the at least two scrambling factor combinations, is received at the terminal from the base station. The one of the at least two scrambling factor combinations is selected based on the second control information. An initial value of a demodulation reference signal sequence is calculated using the selected scrambling factor combination. The demodulation reference signal sequence is received using the initial value.