A wireless device updates a first timing advance of a secondary cell group employing first timing advance command(s) for the secondary cell group. The wireless device stores the first timing advance upon expiry of an associated time alignment timer. The wireless device receives a second timing advance command for the secondary cell group with a timing advance value of zero. The second timing advance command starts the associated time alignment timer. The wireless device transmits uplink signals in radio resources identified in a received uplink grant employing the stored first timing advance.