Various embodiments of systems and methods to provide multi-client generic persistence for extension nodes are described herein. A standard field value and an extension field value specific to a client of a business data object are separated. Further, an extension node instance key associated with the extension field value is segregated. Furthermore, the standard field value and associated standard node instance key are stored in a standard persistence unit, and the extension field value is stored in an extension data persistence unit. Also, the extension node instance key and a relation between the standard node instance key and the extension node instance key are stored in an extension key persistence unit.