Invention Grant
US08936807B2 Use of the cathelicidin LL-37 and derivatives thereof for wound healing
有权
导管素LL-37及其衍生物用于伤口愈合的用途
- Patent Title: Use of the cathelicidin LL-37 and derivatives thereof for wound healing
- Patent Title (中): 导管素LL-37及其衍生物用于伤口愈合的用途
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Application No.: US13938120Application Date: 2013-07-09
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Publication No.: US08936807B2Publication Date: 2015-01-20
- Inventor: Mona Ståhle-Bäckdahl , Johan Heilborn , Anders Carlsson , Conny Bogentoft
- Applicant: Lipopeptide AB
- Applicant Address: SE Stockholm
- Assignee: Lipopeptide AB
- Current Assignee: Lipopeptide AB
- Current Assignee Address: SE Stockholm
- Agency: McCarter & English, LLP
- Agent Steven G. Davis
- Priority: SE0300207 20030129
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61K9/127 ; A61K38/16 ; C12N5/00 ; C12N5/071
Abstract:
Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.
Public/Granted literature
- US20130287839A1 USE OF THE CATHELICIDIN LL-37 AND DERIVATIVES THEREOF FOR WOUND HEALING Public/Granted day:2013-10-31
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