Invention Grant
- Patent Title: Activators of human pyruvate kinase
- Patent Title (中): 人类丙酮酸激酶的活化剂
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Application No.: US13433656Application Date: 2012-03-29
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Publication No.: US08937067B2Publication Date: 2015-01-20
- Inventor: Craig J. Thomas , Douglas S. Auld , James Inglese , Amanda P. Skoumbourdis , Jian-Kang Jiang , Matthew B. Boxer
- Applicant: Craig J. Thomas , Douglas S. Auld , James Inglese , Amanda P. Skoumbourdis , Jian-Kang Jiang , Matthew B. Boxer
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: A61K31/502
- IPC: A61K31/502 ; C07D237/00 ; C07D319/18 ; C07D295/26 ; C07D495/14 ; A61P35/00
Abstract:
Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,
Public/Granted literature
- US20120245141A1 ACTIVATORS OF HUMAN PYRUVATE KINASE Public/Granted day:2012-09-27
Information query
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