Invention Grant
US08937162B2 Humanization of rabbit antibodies using a universal antibody framework
有权
使用通用抗体框架对兔抗体进行人源化
- Patent Title: Humanization of rabbit antibodies using a universal antibody framework
- Patent Title (中): 使用通用抗体框架对兔抗体进行人源化
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Application No.: US13616214Application Date: 2012-09-14
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Publication No.: US08937162B2Publication Date: 2015-01-20
- Inventor: Leonardo Borras , David Urech
- Applicant: Leonardo Borras , David Urech
- Applicant Address: CH
- Assignee: Esbatech, An Alcon Biomedical Research Unit, LLC
- Current Assignee: Esbatech, An Alcon Biomedical Research Unit, LLC
- Current Assignee Address: CH
- Priority: CH0832/09 20090602
- Main IPC: C07K16/18
- IPC: C07K16/18 ; C07K16/22 ; C07K16/24
Abstract:
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
Public/Granted literature
- US20130023652A1 HUMANIZATION OF RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK Public/Granted day:2013-01-24
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