Medical devices, medical procedure trays, kits and related methods are provided for use to perform medical procedures that require access to the interior of a bone. The devices, trays and methods allow multiple use of non-sterile medical devices with sterile medical devices for performing medical procedures requiring sterile conditions. A coupler assembly, capable of releasably attaching to a non-sterile medical device at one end and releasably attaching to one or more sterile medical devices at another end, and further comprising a containment bag which allows maintaining sterility of a non-sterile medical device which may be used in conjunction with sterile medical devices and procedures. The devices, trays, kits and methods enable the performance of multiple medical procedures with a single insertion into bone. For example, a vertebral procedure such as a vertebroplasty may be performed along with biopsy and/or bone marrow aspiration procedures, thereby reducing patient trauma and costs.