Described are method and device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway. The method includes locating a distal end of a closure device adjacent to the passageway. The closure device may include a closure line with proximal and distal ends, an expandable tissue anchor located along the distal end of the closure line, and an expandable occluder member located along the proximal end of the closure line. The expandable tissue anchor is deployed into tissue adjacent to the passageway. The expandable occluder member is deployed adjacent to the passageway such that the expandable occluder member substantially covers the second opening to the passageway.