Invention Grant
US08945558B2 Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
有权
治疗心肌梗塞的方法，包括给予IL-6抑制剂
- Patent Title: Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
- Patent Title (中): 治疗心肌梗塞的方法，包括给予IL-6抑制剂
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Application No.: US12090676Application Date: 2006-10-20
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Publication No.: US08945558B2Publication Date: 2015-02-03
- Inventor: Miyuki Kobara
- Applicant: Miyuki Kobara
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2005-307349 20051021
- International Application: PCT/JP2006/320905 WO 20061020
- International Announcement: WO2007/046489 WO 20070426
- Main IPC: A61P9/10
- IPC: A61P9/10 ; A61K39/395 ; C07K16/24 ; C07K14/715 ; C07K14/54 ; C07K16/28
Abstract:
The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.
Public/Granted literature
- US20090220500A1 AGENTS FOR TREATING CARDIOPATHY Public/Granted day:2009-09-03
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