Invention Grant
US08945567B2 Monovalent, bivalent and trivalent anti human respiratory syncytial virus (HRSV) nanobody constructs for the prevention and/or treatment of respiratory tract infections
有权
用于预防和/或治疗呼吸道感染的单价，二价和三价抗人呼吸道合胞体病毒（HRSV）纳米抗体构建体
- Patent Title: Monovalent, bivalent and trivalent anti human respiratory syncytial virus (HRSV) nanobody constructs for the prevention and/or treatment of respiratory tract infections
- Patent Title (中): 用于预防和/或治疗呼吸道感染的单价，二价和三价抗人呼吸道合胞体病毒（HRSV）纳米抗体构建体
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Application No.: US13375357Application Date: 2010-06-07
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Publication No.: US08945567B2Publication Date: 2015-02-03
- Inventor: Erik Depla , Catelijne Stortelers , Stephanie Staelens
- Applicant: Erik Depla , Catelijne Stortelers , Stephanie Staelens
- Applicant Address: BE Zwijnaarde
- Assignee: Ablynx N.V.
- Current Assignee: Ablynx N.V.
- Current Assignee Address: BE Zwijnaarde
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/EP2010/057921 WO 20100607
- International Announcement: WO2010/139808 WO 20101209
- Main IPC: A61K39/42
- IPC: A61K39/42 ; C07K16/10 ; A61M11/06 ; A61K39/00
Abstract:
Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.
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