Invention Grant
- Patent Title: Ophthalmic device, and method of use thereof, for increasing ocular boundary lubrication
- Patent Title (中): 眼科装置及其使用方法，用于增加眼界润滑
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Application No.: US14032233Application Date: 2013-09-20
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Publication No.: US08945604B2Publication Date: 2015-02-03
- Inventor: Benjamin Sullivan , Tannin A. Schmidt , David A. Sullivan
- Applicant: The Regents of the University of California , Schepens Eye Research Institute
- Applicant Address: US CA Oakland US MA Boston
- Assignee: The Regents of the University of California,Schepens Eye Research Institute
- Current Assignee: The Regents of the University of California,Schepens Eye Research Institute
- Current Assignee Address: US CA Oakland US MA Boston
- Agency: Sutherland Asbill & Brennan LLP
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K47/00 ; A61K38/17 ; A61K31/568 ; A61K31/715 ; A61K38/13 ; A61K38/18 ; A61K45/06
Abstract:
The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device comprises an ophthalmic lens and a sacrificial mechanism disposed on the ophthalmic lens, wherein the sacrificial mechanism comprises a plurality of surface bound receptors, such as PRG4, hyaluronic acid, and DNA aptamers, that reversibly bound to a lubricating composition comprising a gel forming agent, a surfactant, or a combination thereof, effectively inhibiting or preventing protein and lipid adsorption on the surface of the lens, and mitigate shear stress and reduce the friction between the lens and the ocular surface of the individual in need.
Public/Granted literature
- US20140099343A1 Ophthalmic Device, and Method of Use Thereof, for Increasing Ocular Boundary Lubrication Public/Granted day:2014-04-10
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