Invention Grant
US08945609B2 Thermosetting neutralized chitosan composition forming a hydrogel, lyophilizate, and processes for producing the same
有权
形成水凝胶的热固性中和的壳聚糖组合物，冻干，以及其制备方法
- Patent Title: Thermosetting neutralized chitosan composition forming a hydrogel, lyophilizate, and processes for producing the same
- Patent Title (中): 形成水凝胶的热固性中和的壳聚糖组合物，冻干，以及其制备方法
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Application No.: US12158467Application Date: 2005-12-23
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Publication No.: US08945609B2Publication Date: 2015-02-03
- Inventor: Yannic Schuetz , Virginie Caratti-Besson , Oliver Jordan , Robert Gurny
- Applicant: Yannic Schuetz , Virginie Caratti-Besson , Oliver Jordan , Robert Gurny
- Applicant Address: CH Geneva
- Assignee: Laboratoire Medidom S.A.
- Current Assignee: Laboratoire Medidom S.A.
- Current Assignee Address: CH Geneva
- Agency: Faegre Baker Daniels LLP
- International Application: PCT/EP2005/013980 WO 20051223
- International Announcement: WO2007/073749 WO 20070705
- Main IPC: A61L15/00
- IPC: A61L15/00 ; C08L5/08 ; A61K9/00 ; A61K47/36 ; A61L27/20 ; A61L31/04 ; C08B37/08
Abstract:
The aqueous thermosetting neutralized chitosan composition, forming a phosphate-free transparent hydrogel at a temperature higher than 5° C., comprises 0.1 to 5.0 w/w %, based on the total composition, of a reacetylated chitosan having a molecular weight of not smaller than 100 kDa and a deacetylation degree of 40 to 70%, neutralized with an hydroxylated base, and 1 to 30 w/w %, based on the total composition, of a complexing agent selected from polyoses and polyols derived from polyoses. Said composition is useful for the preparation of an injectable formulation.
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