Invention Grant
- Patent Title: Shell-and-core dosage form approaching zero-order drug release
- Patent Title (中): 壳和核心剂型接近零级药物释放
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Application No.: US13688114Application Date: 2012-11-28
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Publication No.: US08945619B2Publication Date: 2015-02-03
- Inventor: Bret Berner , Jenny Louie-Helm , Gloria Gusler , John N. Shell
- Applicant: Depomed, Inc.
- Applicant Address: US CA Newark
- Assignee: Depomed, Inc.
- Current Assignee: Depomed, Inc.
- Current Assignee Address: US CA Newark
- Agency: McDermott Will & Emery LLP
- Main IPC: A61K9/22
- IPC: A61K9/22 ; A61K9/14 ; A61K9/36 ; A61K9/34 ; A61K9/28 ; A61K9/00 ; A61K9/20
Abstract:
Drugs are formulated as oral dosage forms for controlled release in which the release rate limiting portion is a shell surrounding the drug-containing core. The shell releases drug from the core by permitting diffusion of the drug from the core. The shell also motes gastric retention of the dosage form by swelling upon imbibition of gastric fluid to size that is retained in the stomach during the postprandial or fed mode.
Public/Granted literature
- US20130164377A1 SHELL-AND-CORE DOSAGE FORM APPROACHING ZERO-ORDER DRUG RELEASE Public/Granted day:2013-06-27
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