Invention Grant
US08945839B2 CRISPR-Cas systems and methods for altering expression of gene products
有权
CRISPR-Cas系统和改变基因产物表达的方法
- Patent Title: CRISPR-Cas systems and methods for altering expression of gene products
- Patent Title (中): CRISPR-Cas系统和改变基因产物表达的方法
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Application No.: US14256912Application Date: 2014-04-18
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Publication No.: US08945839B2Publication Date: 2015-02-03
- Inventor: Feng Zhang
- Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: The Broad Institute Inc.,Massachusetts Institute of Technology
- Current Assignee: The Broad Institute Inc.,Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/90 ; C12N15/85 ; C12N9/96 ; C12N15/63 ; C12N9/14 ; C12N9/22 ; C12N9/52 ; C12N15/00 ; C07H21/02 ; C07H21/04 ; A61K38/43 ; A61K38/46 ; A61K38/47 ; C12N15/10
Abstract:
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system.
Public/Granted literature
- US20140227787A1 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS Public/Granted day:2014-08-14
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