Invention Grant
US08945865B2 Method for screening for compound capable of enhancing or inhibiting OATP1B1 transport activity, and method for determining expression level of OATP1B1
有权
用于筛选能够增强或抑制OATP1B1转运活性的化合物的方法，以及用于测定OATP1B1表达水平的方法
- Patent Title: Method for screening for compound capable of enhancing or inhibiting OATP1B1 transport activity, and method for determining expression level of OATP1B1
- Patent Title (中): 用于筛选能够增强或抑制OATP1B1转运活性的化合物的方法，以及用于测定OATP1B1表达水平的方法
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Application No.: US14003541Application Date: 2012-03-06
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Publication No.: US08945865B2Publication Date: 2015-02-03
- Inventor: Saki Izumi , Takafumi Komori , Yoshitane Nozaki
- Applicant: Saki Izumi , Takafumi Komori , Yoshitane Nozaki
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JPP2011-053270 20110310
- International Application: PCT/JP2012/055719 WO 20120306
- International Announcement: WO2012/121261 WO 20120913
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N21/64 ; G01N33/50 ; G01N33/58 ; G01N33/68
Abstract:
The present invention provides a method of screening for a compound that enhances or inhibits the transport activity of OATP1B1, using dichlorofluorescein. The present invention also provides a use of dichlorofluorescein in measurement of the expression level of OATP1B1. The present invention further provides a method for measuring the expression level of OATP1B1 in test cells, using dichlorofluorescein. The present invention further provides a use of a kit including dichlorofluorescein and positive cells expressing OATP1B1 in measurement of the expression level of OATP1B1 in test cells.
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