Invention Grant
- Patent Title: Polynucleotides encoding Notch receptor antibodies
- Patent Title (中): 编码Notch受体抗体的多核苷酸
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Application No.: US13782671Application Date: 2013-03-01
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Publication No.: US08945873B2Publication Date: 2015-02-03
- Inventor: Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
- Applicant: OncoMed Pharmaceuticals, Inc.
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N7/01 ; C12N5/12 ; C12N15/09 ; C12N15/63 ; C12N15/79 ; C12P21/08 ; C07K16/28 ; C07K16/30 ; A61K39/395 ; A61K45/06 ; C07K16/46 ; C07K16/22 ; C07K14/705 ; C07K14/71 ; C07K14/435 ; A61K39/00

Abstract:
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
Public/Granted literature
- US20130260455A1 NOTCH BINDING AGENTS AND ANTAGONISTS AND METHODS OF USE THEREOF Public/Granted day:2013-10-03
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