Invention Grant
US08945898B2 Recombinant host cell with deficiency in non-ribosomal peptide synthase production
有权
具有非核糖体肽合成酶生产缺陷的重组宿主细胞
- Patent Title: Recombinant host cell with deficiency in non-ribosomal peptide synthase production
- Patent Title (中): 具有非核糖体肽合成酶生产缺陷的重组宿主细胞
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Application No.: US13806128Application Date: 2011-07-01
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Publication No.: US08945898B2Publication Date: 2015-02-03
- Inventor: Noel Nicolaas Maria Elisabeth Van Peij , Marcus Hans , Martina Beishuizen , Dick Schipper , Robertus Antonius Mijndert Van Der Hoeven , Olaf Leonardus Schouten
- Applicant: Noel Nicolaas Maria Elisabeth Van Peij , Marcus Hans , Martina Beishuizen , Dick Schipper , Robertus Antonius Mijndert Van Der Hoeven , Olaf Leonardus Schouten
- Applicant Address: NL Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: NL Heerlen
- Agency: Miles & Stockbridge, PC
- Priority: EP10168174 20100701; EP11151308 20110118
- International Application: PCT/EP2011/061163 WO 20110701
- International Announcement: WO2012/001169 WO 20120105
- Main IPC: C12N9/96
- IPC: C12N9/96 ; C12P21/02 ; C12N9/18 ; C12N9/00 ; C12N15/80
Abstract:
The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.
Public/Granted literature
- US20130144034A1 METHOD FOR THE PRODUCTION OF A COMPOUND OF INTEREST Public/Granted day:2013-06-06
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