Invention Grant
- Patent Title: Ketol-acid reductoisomerase using NADH
- Patent Title (中): 使用NADH的酮酸酸还原异构酶
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Application No.: US12637905Application Date: 2009-12-15
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Publication No.: US08945899B2Publication Date: 2015-02-03
- Inventor: Yougen Li , Der-Ing Liao , Mark J. Nelson , Daniel P. Okeefe
- Applicant: Yougen Li , Der-Ing Liao , Mark J. Nelson , Daniel P. Okeefe
- Applicant Address: US DE Wilmington
- Assignee: Butamax Advanced Biofuels LLC
- Current Assignee: Butamax Advanced Biofuels LLC
- Current Assignee Address: US DE Wilmington
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N15/00 ; C12P21/06 ; C12P21/04 ; C07H21/04 ; C12N15/81 ; C12N15/70 ; C12N15/10 ; C12N9/04 ; C12P7/16 ; C12P7/42 ; C12Q1/26
Abstract:
Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.
Public/Granted literature
- US20100197519A1 KETOL-ACID REDUCTOISOMERASE USING NADH Public/Granted day:2010-08-05
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