Invention Grant
- Patent Title: Antigen-specific clonal expansion of B cells
- Patent Title (中): B细胞的抗原特异性克隆扩增
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Application No.: US13504638Application Date: 2010-10-29
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Publication No.: US08945923B2Publication Date: 2015-02-03
- Inventor: Ugur Sahin , Ozlem Tureci , Torsten Seppmann , Holger Hoff , Jens Schumacher
- Applicant: Ugur Sahin , Ozlem Tureci , Torsten Seppmann , Holger Hoff , Jens Schumacher
- Applicant Address: DE DE
- Assignee: BioNTech AG,Universitatsmedizin der Johannes Gutenberg-Universitat
- Current Assignee: BioNTech AG,Universitatsmedizin der Johannes Gutenberg-Universitat
- Current Assignee Address: DE DE
- Agency: McAndrews, Held & Malloy, Ltd.
- Priority: EP09013690 20091030
- International Application: PCT/EP2010/006633 WO 20101029
- International Announcement: WO2011/050985 WO 20110505
- Main IPC: A01N1/00
- IPC: A01N1/00 ; C12N5/00 ; C12N5/02 ; C12N5/10 ; C07K14/705
Abstract:
The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.
Public/Granted literature
- US20120219991A1 CLONAL EXPANSION OF B CELLS Public/Granted day:2012-08-30
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