Invention Grant
US08946152B2 Method of treating parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
有权
通过对对角增强输注胶质细胞系衍生的神经营养因子到壳核来治疗人类帕金森病的方法
- Patent Title: Method of treating parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
- Patent Title (中): 通过对对角增强输注胶质细胞系衍生的神经营养因子到壳核来治疗人类帕金森病的方法
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Application No.: US11664943Application Date: 2005-09-22
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Publication No.: US08946152B2Publication Date: 2015-02-03
- Inventor: Steven S. Gill , Don M. Gash , Greg Allen Gerhardt
- Applicant: Steven S. Gill , Don M. Gash , Greg Allen Gerhardt
- Applicant Address: US CA Thousand Oaks US KY Lexington
- Assignee: Amgen Inc.,University of Kentucky Research Foundation
- Current Assignee: Amgen Inc.,University of Kentucky Research Foundation
- Current Assignee Address: US CA Thousand Oaks US KY Lexington
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2005/034347 WO 20050922
- International Announcement: WO2006/044115 WO 20060427
- Main IPC: A61K38/18
- IPC: A61K38/18
Abstract:
A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal mutitiport brain catheters connected to one or moreimplantable pumps wherein the flow rate is pulsed.
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